Coral venom and toxins as protection against crown-of-thorns sea star attack

Gorman, L, Huffmyer, AS, Byrne, M, Mills, SC and Putnam, HM 2026 Coral venom and toxins as protection against crown-of-thorns sea star attack. Molecular Ecology, 35 (1). 10.1111/mec.70202

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Abstract/Summary

Crown-of-thorns sea star (CoTS) outbreaks are a main cause of hard coral cover decline across the Indo-Pacific, posing a major threat to the resilience of coral reefs. However, the drivers underlying CoTS feeding on preferred (e.g., Acropora species) versus non-preferred (e.g., Porites species) are poorly understood. We hypothesised that coral venom may influence CoTS prey preferences. To investigate this hypothesis, we compared the coral venom toxin families across the genomes of preferred (A. digitifera, A. hyacinthus, A. millepora and A. tenuis) and non-preferred (P. australiensis, P. compressa, P. lutea and P. rus) prey species of CoTS. We also included one species from each genus inhabiting the Caribbean, where CoTS are absent (A. cervicornis and P. astreoides), to broaden our identification of venom constituents shared within each genus and investigate geographic differences. We collected known cnidarian toxins, and along with the cnidarian Tox-Prot database, used these to identify putative toxins and investigate their phylogeny. The most abundant toxins across all coral species included neurotoxins (kunitz-type and SCRiPS) and pore-forming toxins (actinoporins and MAC-PFs). We found genera-specific differences with jellyfish toxins (CFXs) only present in Porites species. Similarly, only Acropora species harboured pore-forming toxins with the aerolysin domain. Two toxin homologues only present in Indo-Pacific corals (CFX and MAC-PF homologues) showed evidence of positive selection, suggesting their evolution is shaped by environmental pressures, including exposure to CoTS. These findings provide a foundation for future studies of scleractinian venoms, which have direct applications to assessing reef coral's susceptibility to future CoTS outbreaks and active reef management

Item Type:	Publication - Article
Additional Keywords:	Acropora, crown-of-thorns sea star, neurotoxins, pore-forming toxins, Porites, venom
Subjects:	Biology Ecology and Environment Marine Sciences
Divisions:	Marine Biological Association of the UK > Other (MBA)
Depositing User:	Ms Kristina Hixon
Date made live:	30 Jan 2026 09:12
Last Modified:	30 Jan 2026 09:12
URI:	https://plymsea.ac.uk/id/eprint/10570

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