Chaperones, Canalization, and Evolution of Animal Forms

Sato, A 2018 Chaperones, Canalization, and Evolution of Animal Forms. International Journal of Molecular Sciences, 19 (10). 3029.

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Over half a century ago, British developmental biologist Conrad Hal Waddington proposed the idea of canalization, that is, homeostasis in development. Since the breakthrough that was made by Rutherford and Lindquist (1998), who proposed a role of Hsp90 in developmental buffering, chaperones have gained much attention in the study of canalization. However, recent studies have revealed that a number of other molecules are also potentially involved in canalization. Here, I introduce the emerging role of DnaJ chaperones in canalization. I also discuss how the expression levels of such buffering molecules can be altered, thereby altering organismal development. Since developmental robustness is maternally inherited in various organisms, I propose that dynamic bet hedging, an increase in within-clutch variation in offspring phenotypes that is caused by unpredictable environmental challenges to the mothers, plays a key role in altering the expression levels of buffering molecules. Investigating dynamic bet hedging at the molecular level and how it impacts upon morphological phenotypes will help our understanding of the molecular mechanisms of canalization and evolutionary processes.

Item Type: Publication - Article
Additional Keywords: maternal inheritance; developmental robustness; bet hedging; epigenetic landscape; DNAJs; heat shock proteins
Divisions: Marine Biological Association of the UK > Other (MBA)
Depositing User: Barbara Bultmann
Date made live: 18 Dec 2018 12:39
Last Modified: 25 Apr 2020 09:59

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