Regeneration in sponge Sycon ciliatum mimics postlarval development

Soubigou, A; Ross, EG; Touhami, Y; Chrismas, N; Modepalli, V. 2020 Regeneration in sponge Sycon ciliatum mimics postlarval development. Development, 147 (22). https://doi.org/10.1242/dev.193714

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Abstract/Summary

Somatic cells dissociated from an adult sponge can reorganize and develop into a juvenile-like sponge, a remarkable phenomenon of regeneration. However, the extent to which regeneration recapitulates embryonic developmental pathways has remained enigmatic. We have standardized and established a sponge Sycon ciliatum regeneration protocol from dissociated cells. Morphological analysis demonstrated that dissociated sponge cells follow a series of morphological events resembling postembryonic development. We performed high-throughput sequencing on regenerating samples and compared the data with that from regular postlarval development. Our comparative transcriptomic analysis revealed that sponge regeneration is as equally dynamic as embryogenesis. We found that sponge regeneration is orchestrated by recruiting pathways similar to those utilized in embryonic development. We also demonstrated that sponge regeneration is accompanied by cell death at early stages, revealing the importance of apoptosis in remodelling the primmorphs to initiate re-development. Because sponges are likely to be the first branch of extant multicellular animals, we suggest that this system can be explored to study the genetic features underlying the evolution of multicellularity and regeneration

Item Type: Publication - Article
Additional Keywords: Development, Evolution, Multicellularity, Regeneration, Sycon ciliatum
Subjects: Marine Sciences
Divisions: Marine Biological Association of the UK > Mechanisms underlying biogeochemical and ecological processes > Marine Microbial Biochemistry
Depositing User: Emily Smart
Date made live: 28 Sep 2021 14:34
Last Modified: 28 Sep 2021 14:34
URI: http://plymsea.ac.uk/id/eprint/9379

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