Sponge-Inspired Dibromohemibastadin Prevents and Disrupts Bacterial Biofilms without Toxicity

Le Norcy, T; Niemann, H; Proksch, P; Tait, K; Linossier, I; Réhel, K; Hellio, C; Faÿ, F. 2017 Sponge-Inspired Dibromohemibastadin Prevents and Disrupts Bacterial Biofilms without Toxicity. Marine Drugs, 15 (7). 222. https://doi.org/10.3390/md15070222

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Official URL: http://www.mdpi.com/1660-3397/15/7/222

Abstract/Summary

Since the banning of several families of compounds in antifouling (AF) coatings, the search for environmentally friendly AF compounds has intensified. Natural sources of AF compounds have been identified in marine organisms and can be used to create analogues in laboratory. In a previous study, we identified that dibromohemibastadin-1 (DBHB) is a promising AF molecule, leading to the inhibition of the activity of phenoloxidase, an enzyme involved in the attachment of mussels to surfaces. This paper describes the activity of the DBHB on biofilm formation and its detachment and on bacterial adhesion and communication: quorum sensing. DBHB has an anti-biofilm activity without affecting adhesion of marine and terrestrial bacteria at a dose of 10 µM. Moreover, DBHB activity on quorum sensing (QS) is demonstrated at doses of 8 and 16 µM. The activity of DBHB on QS is compared to kojic acid, a quorum sensing inhibitor already described. This compound is a promising environmentally friendly molecule potentially useful for the inhibition of microfouling.

Item Type: Publication - Article
Subjects: Marine Sciences
Divisions: Plymouth Marine Laboratory > Science Areas > Marine Ecology and Biodiversity
Depositing User: Karen Tait
Date made live: 23 Jul 2018 15:07
Last Modified: 23 Jul 2018 15:07
URI: http://plymsea.ac.uk/id/eprint/7536

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