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Barón, E, Dissanayake, AD, Vilà-Cano, J, Crowther, C, Readman, JW, Jha, AN, Eljarrat, E and Barceló, D 2016 Evaluation of the Genotoxic and Physiological Effects of Decabromodiphenyl Ether (BDE-209) and Dechlorane Plus (DP) Flame Retardants in Marine Mussels (Mytilus galloprovincialis). Environmental Science & Technology, 50 (5). 2700-2708. https://doi.org/10.1021/acs.est.5b05814
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Baron et al EST in press 2016.pdf - Accepted Version Available under License Creative Commons Attribution Non-commercial. Download (1MB) | Preview |
Abstract/Summary
Dechlorane Plus (DP) is a proposed alternative to the legacy flame retardant decabromodiphenyl ether (BDE-209), a major component of Deca-BDE formulations. In contrast to BDE-209, toxicity data for DP are scarce and often focused on mice. Validated dietary in vivo exposure of the marine bivalve (Mytilus galloprovincialis) to both flame retardants did not induce effects at the physiological level (algal clearance rate), but induced DNA damage, as determined by the comet assay, at all concentrations tested. Micronuclei formation was induced by both DP and BDE-209 at the highest exposure concentrations (100 and 200 mu g/L, respectively, at 18% above controls). DP caused effects similar to those by BDE-209 but at lower exposure concentrations (5.6, 56, and 100 mu g/L for DP and 56, 100, and 200 mu g/L for BDE-209). Moreover, bioaccumulation of DP was shown to be concentration dependent, in contrast to BDE-209. The results described suggest that DP poses a greater genotoxic potential than BDE-209
| Item Type: | Publication - Article |
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| Additional Keywords: | POLYBROMINATED DIPHENYL ETHERS; PRESSURIZED LIQUID EXTRACTION; DNA-DAMAGE; COMET ASSAY; DREISSENA-POLYMORPHA; TROPHIC TRANSFER; RISK-ASSESSMENT; FOOD-WEB; EXPOSURE; SEDIMENT |
| Subjects: | Ecology and Environment Marine Sciences |
| Divisions: | Plymouth Marine Laboratory > Other (PML) |
| Depositing User: | Mrs Julia Crocker |
| Date made live: | 09 Jun 2016 13:22 |
| Last Modified: | 25 Apr 2020 09:57 |
| URI: | https://plymsea.ac.uk/id/eprint/7098 |
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