Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds

Alvarez-Munoz, D; Indiveri, P; Rostkowski, P; Horwood, J; Greer, E; Minier, C; Pope, ND; Langston, WJ; Hill, EM. 2015 Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds. Marine Pollution Bulletin, 95 (2). 590-597. 10.1016/j.marpolbul.2014.11.014

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Official URL: http://dx.doi.org/10.1016/j.marpolbul.2014.11.014

Abstract/Summary

This study analysed the levels of androgen receptor antagonist activity in extracts of coastal sediments sampled from estuaries in southern UK and northern France. Anti-androgenic (AA) activity varied between <0.2 and 224.3±38.4μg flutamide equivalents/g dry weight of sediment and was significantly correlated with the total organic carbon and silt content of samples. AA activity was detected in tissues extracts of clams, Scrobicularia plana, sampled from a contaminated estuary, some of which was due to uptake of a series of 4 or 5 ring polycyclic aromatic hydrocarbons (PAHs). Initial studies also indicated that fractionated extracts of male, but not female, clams also contained androgen receptor agonist activity due to the presence of dihydrotestosterone in tissues. This study reveals widespread contamination of coastal sediments of the Transmanche region with anti-androgenic compounds and these contaminants should be investigated for their potential to disrupt sexual differentiation in aquatic organisms.

Item Type: Publication - Article
Divisions: Marine Biological Association of the UK > Other (MBA)
Depositing User: Barbara Bultmann
Date made live: 03 Oct 2016 14:05
Last Modified: 06 Jun 2017 16:17
URI: http://plymsea.ac.uk/id/eprint/7217

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